Biology idea 2: The gene
Why do offspring resemble their parents? The discovery of the molecule that is passed from a parent to their offspring was a key development in biology.
Discovering heredity
The nature of heredity was discovered by a monk called Gregor Mendel who carried out thousands of breeding experiments with pea plants. From his results, he surmised that a 'particle' from each parent is passed on to their offspring and that these two 'particles' interact to create similar traits in the offspring.
Inheritance of traits
Even though Mendel had clearly shown inheritance involved a particle being passed from parent to offspring, he had not been able to identify the particle, so his work was treated with scepticism. Almost half a century later, in the early 1900s, these views were changed.
Mendel: The father of genetics
Using peas, maths, and a lot of patience, Gregor Mendel uncovered some of the secrets of the gene. Nobel prize winner Sir Paul Nurse explains some of the monk's ground-breaking conclusions.
Mendel: The father of genetics
Using peas, maths, and a lot of patience, Gregor Mendel uncovered some of the secrets of the gene. Nobel prize winner Sir Paul Nurse explains some of the monk's ground-breaking conclusions.
Mendel: Ahead of his time
When Gregor Mendel published his theory of inheritance in 1865, it should have started a revolution. Charles Darwin had published The Origin of Species six years earlier. Its major omission was any kind of explanation for the mechanism of heredity, which Mendel's work supplied. However, it would be another 35 years before his theory would be rediscovered and then accepted. What changed?
Mendel: Ahead of his time
When Gregor Mendel published his theory of inheritance in 1865, it should have started a revolution. Charles Darwin had published The Origin of Species six years earlier. Its major omission was any kind of explanation for the mechanism of heredity, which Mendel's work supplied. However, it would be another 35 years before his theory would be rediscovered and then accepted. What changed?
Could the secrets to heredity lie inside cells? Chromosomes had been observed and behaved exactly as Mendel’s particles should, but how they could carry hereditary information was still a mystery.
The central dogma of biology
Mendel’s work was finally accepted when DNA was identified as the molecule responsible for inheritance. DNA has functional lengths called genes that equate to Mendel’s particles. These lengths of DNA control a trait by way of producing a protein. This is the central dogma of biology.
From Mendel to DNA
The rediscovery of Mendel's work in 1900 began a series of revelations about genetics that would continue throughout the 20th century. What were some of these revelations?
DNA is normally found inside cells in a structure called the nucleus. In the nucleus, the DNA is unravelled. However, when DNA is being replicated, it becomes tightly wound into fibres and forms structures called chromosomes.
Genes are inherited
We now know that genes are the unit of inheritance. We inherit two copies of each gene, one from each of our parents.
All the cells we have contain exactly the same genes, but not all of these genes are expressed. Some genes are switched on to produce proteins, whereas others are switched off. The type of cell, tissue or organ depends on which genes are expressed.
