Fighting infection – introduction

We all get sick from time to time. Wintertime, in particular, brings with it colds and flus.

Sick child

See more

We all get sick from time to time and don’t feel too good. At this time, our bodies are busy working to make us well.

Rights: Image licensed through 123rf.com

Symptoms may include feeling hot and cold, a runny nose, streaming eyes, headaches, tiredness, loss of appetite, then after a few days (or sometimes longer), we start to feel better and are back to normal. So what is happening? Why do we feel so terrible? How do we get better? What is going on inside our bodies?

Let’s investigate…

Infection is the invasion of pathogenic (disease-causing) microorganisms in the body and the body’s response to that.

Pathogenic microorganisms, commonly called germs or bugs, are all around us. They can be easily transmitted from one person to another. Once they get past your skin (part of your first line of defence), they get into your body, your bloodstream and your cells. At this point, your immune system (your second line of defence) kicks in and fights back to destroy the pathogens causing infection.

Killer T cells.

See more

Immune cells known as killer T cells help to fight infection in our bodies.

Rights: Science Photo Library

The immune system

The immune system consists of cells, tissues and organs that work together to protect you. We explore the immune system and how it responds to various microorganisms.

In the article The body’s second line of defence, we look at microorganisms, including some of the pathogens that cause sickness.

Hand washing and hygiene practices are vital to stopping the spread of infection. In the 1880s, Florence Nightingale was well aware of the importance of hand washing even though microorganisms were not fully understood at that time.

Every nurse ought to be careful to wash her hands very frequently during the day. If her face, too, so much the better.”

Florence Nightingale

We find out what happens when your immune system doesn’t work through the story of David Vetter who lived in a sterile bubble all his life.

We also take a look at vaccination. This is a way of preventing some diseases by using your immune system to protect you. Vaccination became a global focus with the COVID-19 pandemic. We look at the history of vaccination, as well as current immunisation in New Zealand. This is supported by activities including an investigation into some of the ethical issues surrounding vaccination.

Māori perspectives

We explore rongoā – the Māori term for medicines that are produced from native plants in New Zealand. Many of these plants were and are still used to fight infection. Find out more in the article Rongoā Māori and then follow up with the activity Using rongoā Māori.

Antimicrobial resistance

Any use of antibiotics automatically creates resistance. Learn why it is an issue, the history of antibiotics and antimicrobial resistance and what you can do to reduce the risk. The context for learning provides ideas on how to incorporate this wicked problem into authentic cross-curricular learning.

The Infection Inspection citizen science project is using E. coli to help develop a faster test for antibiotic resistance. They need your observation skills to help identify bacteria that have been impacted by antibiotics. This is an engaging way to introduce science concepts.

Meet the scientists

Scientists from the Malaghan Institute of Medical Research in Wellington share their research. The article Hookworm and allergies profiles the work of Professor Graham Le Gros, who is working on a vaccine against asthma and allergies. Dr Joanna Kirman explores infectious diseases, like tuberculosis, and how they affect the immune system. This helps her team find cures for these diseases. Dr Bridget Stocker and Dr Mattie Timmer design drugs and make molecules to improve vaccines.

Research being conducted at the Malaghan Institute

See more

Dr Mattie Timmer and PhD student Anna Win-Mason carry out research at the Malaghan Institute of Medical Research.

Rights: The University of Waikato Te Whare Wānanga o Waikato

Take up the challenge

We also have some great activity ideas that cover some of the big ideas in science.

• Cells: Introduction to cells and Inside a cell

• DNA: Extracting DNA

• Immune system: The wars within, Fighting infection card game, Making snot and Spreading diseases

• Medical research and ethics: Exploring medical research, Ethical dilemmas in fighting infection and Managing classroom discussions

There are also cross-curricular opportunities: Literacy in immunology and Drama with microbes.

Curious to see how all of this fits together? Check out the unit plans: Fighting infection – the immune system and Fighting infection – reducing infection.

Being a scientist is a lot like being a detective – you have to think of cunning ways to solve problems and find the answers.

Dr Joanna Kirman (Malaghan Institute of Medical Research)

Question bank

The Fighting infection – question bank provides a list of questions about the immune system, pathogens, vaccines and places where their answers can be found. The questions support an inquiry approach.

Key terms

For explanations of key concepts, see Fighting infection – key terms.

Timeline

Use this timeline to see some of the historical aspects of fighting infection, covering early discoveries on germs, vaccination, how are our bodies help us to get better and more.